报错如下：

Uncaught TypeError: Cannot read property 'modules' of undefined
    at Object.eval (webpack-internal:///./node_modules/bindings/bindings.js:29)
    at eval (webpack-internal:///./node_modules/bindings/bindings.js:223)
    at Object../node_modules/bindings/bindings.js (chunk-vendors.js:255)
    at __webpack_require__ (app.js:849)
    at fn (app.js:151)
    at eval (webpack-internal:///./node_modules/@serialport/bindings/lib/linux.js:2)
    at Object../node_modules/@serialport/bindings/lib/linux.js (chunk-vendors.js:65)
    at __webpack_require__ (app.js:849)
    at fn (app.js:151)
    at Object.eval (webpack-internal:///./node_modules/@serialport/bindings/lib/index.js:14)

总结下来：webpack不能解析二进制什么的...github有讨论

系统：win10  
"dependencies": {
    "core-js": "^3.6.5",
    "electron-prebuilt": "^1.4.13",
    "serialport": "^9.2.1",
    "vue": "^2.6.11"
},
"devDependencies": {
    "@vue/cli-plugin-babel": "~4.5.0",
    "@vue/cli-plugin-eslint": "~4.5.0",
    "@vue/cli-service": "~4.5.0",
    "babel-eslint": "^10.1.0",
    "electron": "^13.0.0",
    "electron-devtools-installer": "^3.1.0",
    "electron-rebuild": "^3.2.3",
    "eslint": "^6.7.2",
    "eslint-plugin-vue": "^6.2.2",
    "vue-cli-plugin-electron-builder": "~2.1.1",
    "vue-template-compiler": "^2.6.11"
},

解决方法：

const { IgnorePlugin } = require('webpack')

module.exports = {
  pluginOptions: {
    plugins: [
      new IgnorePlugin({
        resourceRegExp: /serialport/
      })
    ],
    electronBuilder: {
      nodeIntegration: true,
      externals: [
        'serialport'
      ]
    }
  }
}

app.allowRendererProcessReuse = false

 重新运行即可